The Science City of Muñoz is a 5th class city in the province of Nueva Ecija, Philippines. According to the 2000 census, it has a population of 65,586 people in 13,940 households.

In 2000, the municipality of Muñoz was converted into a city named the Science City of Muñoz.[1] It earned the new title due to numerous scientific institutions situated within the town which include Central Luzon State University (CLSU), Philippine Rice Research Institute (PhilRice), Bureau of Postharvest Research and Extension (BPRE), Philippine Carabao Center (PCC), and Bureau of Fisheries and Aquatic Resources (BFAR), Philippine-Sino Center for Agricultural Technology (PhilSCAT), Philippine Seed Center.

On January 1, 2008, the Philippine Carabao Center in Nueva Ecija, per Filipino scientists initiated a study to breed the super water buffalo that could produce 4 to 18 liters of milk/day (gene-based technology). Also, the 1st test-tube hybrid carabao was born thereat in 2004, “Glory,” named after President Gloria Macapagal-Arroyo. Joseph Estrada’s most successful project as an opposition senator, the PCC was created through Republic Act 3707, the Carabao Act of 1992.

From Sitio to Barrio

In 1886, Papaya was changed into 'Muñoz' to honor Don Francisco Muñoz, the province’s alcalde mayor, and the community’s first appointed gobernadorcillo. Muñoz was annexed as a barrio of San Juan de Guimba municipality. Settlers trickled in from Bulacan and the Ilocos Region. In 1911, Factoria (now San Isidro town), the provincial capital, was totally flooded. Muñoz was then considered a possible new capital of the province.