Santo Domingo (or Sto. Domingo) is a 3rd class municipality in the province of Nueva Ecija, Philippines. According to the latest census, it has a population of 47,960 people in 9,532 households.

It is bordered by the municipalities of Talavera and Quezon.

Barangays

Santo Domingo is politically subdivided into 24 barangays.

* Baloc
* Buasao
* Burgos
* Cabugao
* Casulucan
* Comitang
* Concepcion
* Dolores
* General Luna
* Hulo
* Mabini
* Malasin
* Malayantoc
* Mambarao
* Poblacion
* Malaya (Pook Malaya)
* Pulong Buli
* Sagaba
* San Agustin
* San Fabian
* San Francisco
* San Pascual
* Santa Rita
* Santo Rosario